CBD Addiction: Is Cannabidiol CBD Addictive?

Main findings from clinical and animal studies aimed to evaluate the therapeutic potential of CBD for the treatment of stimulant use disorder. According to the previous evidence, it seems that CBD could play a crucial role in the management of CUD. The clinical studies that are underway as well as future investigations will be decisive to determine the therapeutic application of CBD to treat cannabis addiction. Nabiximols (Sativex; containing THC 2.7 mg/dose and CBD 2.5 mg/dose) has been found to significantly reduce scores on the cannabis withdrawal scale, as well as cravings, irritability, and depression in cannabis dependent individuals (Allsop et al., 2014). Three-month treatment with Sativex (up to 113.4 of THC/105 mg of CBD) concurrent with weekly motivational enhancement therapy and cognitive behavioral therapy reduced cannabis use with no significant increases in withdrawal in cannabis-dependent participants. Craving scores increased during the first two weeks but progressively returned to baseline levels from the third week of treatment (Trigo et al., 2016) (Table 2).

Is CBD addictive?

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• Amphetamine-type stimulants include substances with a similar chemical structure, such as amphetamine and methamphetamine, and other structurally different but with similar effects, such as methylphenidate.
• Sometimes spotting addictive behaviors in individuals can be difficult, but learning how to recognize the signs can help you or your loved ones get the help they need sooner.

A study published in the Journal of Drug and Alcohol Dependence compared the potential for dependence between CBD and a placebo. CBD works by interacting with the body’s endocannabinoid system (ECS), a complex network of receptors and neurotransmitters that help regulate various bodily functions, including pain, mood, and sleep. While the exact mechanisms are still being studied, it’s believed that CBD helps maintain balance within the ECS, which could explain its broad range of potential benefits. The present review shows the current state of the art about the potential interest of CBD as a new pharmacological avenue for SUD. According to the findings from preclinical and clinical studies, CBD alone or in combination with commonly employed treatment strategies in drug addiction may configure a potential therapeutic option for improving the dishabituation process of addicted patients. In recent years, the major role of hippocampal neurogenesis in the addictive process has become increasingly established (Mandyam and Koob, 2012; Chambers, 2013; Deroche-Gamonet et al., 2019).

Effects of CBD on tobacco-related addictive behaviors

He also suggests “engaging in mentally stimulating activities,” which help “strengthen neural pathways and restore executive function,” like reading, writing and problem-solving. Although some studies have linked cognitive deficits to problematic cannabis use, the good news is that these are generally regarded as reversible, unlike with alcohol or methamphetamines which can cause permanent brain damage. Plus, enjoy free shipping and a free gift on orders over $75 within the U.S. High doses of CBD can lead to liver-related issues, similar to those caused by other medications like acetaminophen.

What Is HRV and Why Does It Matter for Sleep?

For example, CBD may bind to the CB1 receptor, which are found in the central nervous system, to improve your mood. Or, it may interact with CB2 receptors in immune tissue to reduce swelling around joints. CBD has been studied in several conditions with an inflammatory component, including gastrointestinal inflammation, ulcerative colitis, ocular hypertension, glaucoma and diabetes. However, CBD has not shown benefit in these studies, and more information is required.

THC: Psychoactive and Therapeutic Effects

Daily consumption of CBD products is reportedly the most effective way to achieve and maintain positive results. THC, for instance, binds to the brain and body’s CB1 and CB2 endocannabinoid system (ECS) receptors. A 2020 review published in Cannabis and Cannabinoid Research examined existing amphetamine addiction treatment clinical and pre-clinical evidence.

However, state laws can vary, creating a confusing legal landscape for users. Navigating these legal intricacies is crucial for those seeking to incorporate CBD into their wellness routine. Cannabinoids are in cannabis plants, but they also exist in smaller amounts in other plants. Some non-cannabis sources of cannabinoids include black pepper, echinacea, cacao, and liverworts.2 While these plants do not contain THC or CBD, they have compounds that interact with the endocannabinoid system in similar ways. Cannabis also contains smaller amounts of other cannabinoids, which researchers are still exploring. Minor cannabinoids still play a useful role in the overall effects of cannabis, and several have grown in popularity for their specific properties.

For example, CBD is known to interact with liver enzymes, like CYP3A4, which can dangerously raise the plasma concentration of these drugs. Activating these receptors doesn’t cause impairment but may help reduce inflammation and pain. Cannabinoids like cannabidiol (CBD) interact with CB2 receptors, offering potential anti-inflammatory benefits. Because THC can produce significant euphoric and pleasurable effects, there’s a chance that marijuana users will continue to seek out the gratifying drug-induced experience. As a result, dependency or frequent use can occur as a result of elevated dopamine levels is cbd addictive and lowered tolerance. Essentially, the continuous flood of dopamine caused by THC can result in the brain becoming less responsive to dopamine signals, requiring higher amounts of the substance to achieve the same level of pleasure or reward.